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Article

Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil.

Malaria journal - 20 Nov 2008

Sutherland Colin J, Laundy Matt, Price Nicholas, Burke Martina, Fivelman Quinton L, Pasvol Geoffrey, Klein John L, Chiodini Peter L

Abstract excerpt

BACKGROUND: Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine. Atovaquone-proguanil is one such combination drug used both for prophylaxis in travellers, and for treatment of acute malaria cases in European hospitals and clinics. METHODS: A series of eight...

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Identifiers

PMID: 19021900
DOI: 10.1186/1475-2875-7-240
PMCID: PMC2640403

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