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Article

Failure of atovaquone-proguanil malaria chemoprophylaxis in a traveler to Ghana.

Travel medicine and infectious disease - 1 Jan 2000

Boggild Andrea K, Lau Rachel, Reynaud Denis, Kain Kevin C, Gerson Marvin

Abstract excerpt

Clinical failure of Malarone™ chemoprophylaxis is extremely rare. We report a case of Plasmodium falciparum malaria in a returned traveler to Ghana who fully adhered to atovaquone-proguanil (Malarone™) chemoprophylaxis daily dosing, yet took the pills on an empty stomach. Screening of the P. falciparum isolate revealed triple codon mutation of Dhfr at positions 51, 59, and 108. Plasma drug levels of both...

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Identifiers

PMID: 25582377
DOI: 10.1016/j.tmaid.2014.12.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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