Article
Molecular characterization of the cytochrome b gene and in vitro atovaquone susceptibility of Plasmodium falciparum isolates from Kenya.
Antimicrobial agents and chemotherapy - 1 Mar 2015
Ingasia Luicer A, Akala Hoseah M, Imbuga Mabel O, Opot Benjamin H, Eyase Fredrick L, Johnson Jacob D, Bulimo Wallace D, Kamau Edwin
Abstract excerpt
The prevalence of a genetic polymorphism(s) at codon 268 in the cytochrome b gene, which is associated with failure of atovaquone-proguanil treatment, was analyzed in 227 Plasmodium falciparum parasites from western Kenya. The prevalence of the wild-type allele was 63%, and that of the Y268S (denoting a Y-to-S change at position 268) mutant allele was 2%. There were no pure Y268C or Y268N mutant alleles, only...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.