Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35.

doi:10.1086/422475

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Article

Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35.

American journal of human genetics - 1 Aug 2004

Marazita Mary L, Murray Jeffrey C, Lidral Andrew C, Arcos-Burgos Mauricio, Cooper Margaret E, Goldstein Toby, Maher Brion S, Daack-Hirsch Sandra, Schultz Rebecca, Mansilla M Adela, Field L Leigh, Liu You-e, Prescott Natalie, Malcolm Sue, Winter Robin, Ray Ajit, Moreno Lina, Valencia Consuelo, Neiswanger Katherine, Wyszynski Diego F, Bailey-Wilson Joan E, Albacha-Hejazi Hasan, Beaty Terri H, McIntosh Iain, Hetmanski Jacqueline B, Tunçbilek Gökhan, Edwards Matthew, Harkin Louise, Scott Rodney, Roddick Laurence G

Abstract excerpt

Isolated or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect with a complex etiology. A 10-cM genome scan of 388 extended multiplex families with CL/P from seven diverse populations (2,551 genotyped individuals) revealed CL/P genes in six chromosomal regions, including a novel region at 9q21 (heterogeneity LOD score [HLOD]=6.6). In addition, meta-analyses with the addition of...

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PMID: 15185170
DOI: 10.1086/422475
PMCID: PMC1216052

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