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Article

A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23.

American journal of medical genetics. Part A - 15 Apr 2007

Riley B M, Schultz R E, Cooper M E, Goldstein-McHenry T, Daack-Hirsch S, Lee K T, Dragan E, Vieira A R, Lidral A C, Marazita M L, Murray J C

Abstract excerpt

Isolated or nonsyndromic cleft lip and palate (NS CLP) is a complex disorder resulting from multiple genetic and environmental factors. NS CLP has a birth prevalence of 1 per 500 in the Philippines where large families provide an opportunity for gene localization. Genotyping of 392 microsatellite...

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Share to Adaptor Proteins, Signal Transducing
Share to Chromosomes, Human, Pair 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 17366557
DOI: 10.1002/ajmg.a.31673
PMCID: PMC2570349

Genes

FGFR1
BAG4
EGR3
EPHX2
FZD3
NAT1
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17366557-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23.PMID 17366557Read ↗

Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35.Semantic proximity Read ↗

A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24.Semantic proximity Read ↗

Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results.Semantic proximity Read ↗

Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.Semantic proximity Read ↗

Discovery of candidate genes for nonsyndromic cleft lip palate through genome-wide linkage analysis of large extended families in the Malay population.Semantic proximity Read ↗

Identification of novel susceptibility genes for non-syndromic cleft lip with or without cleft palate using NGS-based multigene panel testing.Semantic proximity Read ↗

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.Semantic proximity Read ↗

Targeted scan of fifteen regions for nonsyndromic cleft lip and palate in Filipino families.Semantic proximity Read ↗

Genome-wide association study of multiethnic non-syndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypesSemantic proximity Read ↗

Exploration of Genetic Variants of Non-syndromic Cleft Lip with or without Palate and Underlying Mechanisms.Semantic proximity Read ↗

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.Semantic proximity Read ↗

Identification of susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a two stage genome scan of affected sib-pairs.Semantic proximity Read ↗

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