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Article

A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23.

American journal of medical genetics. Part A - 15 Apr 2007

Riley B M, Schultz R E, Cooper M E, Goldstein-McHenry T, Daack-Hirsch S, Lee K T, Dragan E, Vieira A R, Lidral A C, Marazita M L, Murray J C

Abstract excerpt

Isolated or nonsyndromic cleft lip and palate (NS CLP) is a complex disorder resulting from multiple genetic and environmental factors. NS CLP has a birth prevalence of 1 per 500 in the Philippines where large families provide an opportunity for gene localization. Genotyping of 392 microsatellite repeat markers at 10 cM intervals over the genome was performed by the Center for Inherited Disease Research (CIDR) on...

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Source

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Identifiers

PMID: 17366557
DOI: 10.1002/ajmg.a.31673
PMCID: PMC2570349

Genes

FGFR1
BAG4
EGR3
EPHX2
FZD3
NAT1
NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23.PMID 17366557Read ↗

Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35.Semantic proximity Read ↗

A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24.Semantic proximity Read ↗

Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results.Semantic proximity Read ↗

Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.Semantic proximity Read ↗

Discovery of candidate genes for nonsyndromic cleft lip palate through genome-wide linkage analysis of large extended families in the Malay population.Semantic proximity Read ↗

Identification of novel susceptibility genes for non-syndromic cleft lip with or without cleft palate using NGS-based multigene panel testing.Semantic proximity Read ↗

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.Semantic proximity Read ↗

Targeted scan of fifteen regions for nonsyndromic cleft lip and palate in Filipino families.Semantic proximity Read ↗

Genome-wide association study of multiethnic non-syndromic orofacial cleft families identifies novel loci specific to family and phenotypic subtypesSemantic proximity Read ↗

Exploration of Genetic Variants of Non-syndromic Cleft Lip with or without Palate and Underlying Mechanisms.Semantic proximity Read ↗

Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.Semantic proximity Read ↗

Identification of susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a two stage genome scan of affected sib-pairs.Semantic proximity Read ↗

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