Article
Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results.
Human heredity - 1 Jan 2009
Marazita Mary L, Lidral Andrew C, Murray Jeffrey C, Field L Leigh, Maher Brion S, Goldstein McHenry Toby, Cooper Margaret E, Govil Manika, Daack-Hirsch Sandra, Riley Bridget, Jugessur Astanand, Felix Temis, Morene Lina, Mansilla M Adela, Vieira Alexandre R, Doheny Kim, Pugh Elizabeth, Valencia-Ramirez Consuelo, Arcos-Burgos Mauricio
Abstract excerpt
OBJECTIVES: Non-syndromic orofacial clefts, i.e. cleft lip (CL) and cleft palate (CP), are among the most common birth defects. The goal of this study was to identify genomic regions and genes for CL with or without CP (CL/P). METHODS: We performed linkage analyses of a 10 cM genome scan in 820 multiplex CL/P families (6,565 individuals). Significant linkage results were followed by association analyses of 1,476...
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