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Article

Hepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patient.

Journal of clinical microbiology - 1 Jun 2004

Alexopoulou Alexandra, Baltayiannis Gerasimos, Jammeh Saffie, Waters Jenny, Dourakis Spyros P, Karayiannis Peter

Abstract excerpt

A patient with agammaglobulinemia developed acute hepatitis that progressed to chronic liver disease with high levels of hepatitis B virus (HBV) DNA in the absence of detectable HBsAg. Sequencing of the a determinant region of HBsAg revealed multiple amino acid substitutions that, unusually, also included a substitution at position 122 that defines subtype specificity. All of these mutations had a profound effect...

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Share to Agammaglobulinemia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15184493
DOI: 10.1128/JCM.42.6.2861-2865.2004
PMCID: PMC427883

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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