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Article

Effect of variation in the common ?a? determinant on the antigenicity of hepatitis B surface antigen

1 Feb 2000

Abstract excerpt

Antibody to the common "a" determinant of hepatitis B surface antigen (HBsAg) protects against infection with hepatitis B virus. A number of variant surface antigens with amino acid substitutions within the "a" determinant have been described in patients around the world. Both wild type and variant HBsAgs were expressed in the yeast Pichia pastoris and the antigens were semi-purified and quantitated. The effect...

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Identifiers

PMID: 10596008
DOI: 10.1002/(sici)1096-9071(200002)60:2<113::aid-jmv2>3.0.co;2-0

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