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Article

Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls.

21 Nov 1995

Abstract excerpt

The human hepatitis B virus (HBV) HBx protein is a small transcriptional activator that is essential for virus infection. HBx is thought to be involved in viral hepatocarcinogenesis because it promotes tumorigenesis in transgenic mice. HBx activates the RAS-RAF-mitogen-activated protein (MAP) kinase signaling cascade, through which it activates transcription factors AP-1 and NF-kappa B, and stimulates cell DNA...

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Identifiers

PMID: 7479968
DOI: 10.1073/pnas.92.24.11215

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Source receipt: pubmed, retrieved 7 Sept 2026.

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