Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53

doi:10.1099/0022-1317-83-11-2765

Article

Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53

1 Nov 2002

Abstract excerpt

Despite the extensive studies on the roles of hepatitis B virus (HBV) X protein (HBx) in the development of hepatocellular carcinomas (HCCs), the mechanisms by which HBx contributes to HCC remain controversial. In this study, the effect of HBx on the G(1)-S checkpoint control depending on the status of p53 was compared. Transcription of p21(waf1/cip1) was activated by HBx in the presence of functional p53 in a...

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