Article
Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathway.
Gene - 5 Sept 2001
Ahn J Y, Chung E Y, Kwun H J, Jang K L
Abstract excerpt
The X-gene product of hepatitis B virus (HBx) has been implicated in hepatitis B virus (HBV)-mediated hepatocellular carcinoma through its ability to induce liver cancer in some transgenic mice and to transactivate a variety of viral and cellular promoters. In this study, we demonstrated that the level of p21(waf1) RNA was decreased in the HBx-expressing cells and this effect was due to the transcriptional...
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