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Article

Rapid self-assembly of alpha-synuclein observed by in situ atomic force microscopy.

Journal of molecular biology - 25 Jun 2004

Hoyer Wolfgang, Cherny Dmitry, Subramaniam Vinod, Jovin Thomas M

Abstract excerpt

Self-assembly of alpha-synuclein resulting in protein aggregates of diverse morphology has been implicated in the pathogenesis of Parkinson's disease and other neurodegenerative disorders known as synucleinopathies. Apart from its biomedical relevance, this aggregation process is representative of the interconversion of an unfolded protein into nanostructures with typical amyloid features. We have used in situ...

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Identifiers

PMID: 15184027
DOI: 10.1016/j.jmb.2004.04.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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