Article
The chaperoning and assistance roles of the HIV-1 nucleocapsid protein in proviral DNA synthesis and maintenance.
The international journal of biochemistry & cell biology - 1 Sept 2004
Bampi Carole, Jacquenet Sandrine, Lener Daniela, Décimo Didier, Darlix Jean-Luc
Abstract excerpt
In the following three sections, we will briefly review the seminal roles of the HIV-1 nucleocapsid protein p7 (NCp7) in the fate of the HIV-1 full length RNA from genomic RNA in a dimeric form to the proviral DNA. Emphasis will be given to the mechanisms of NC-directed assistance to the genomic RNA and reverse transcriptase (RT) in the course of proviral DNA synthesis and to DNA integrity at the end of the...
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