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Article

Nucleocapsid mutations turn HIV-1 into a DNA-containing virus.

Nucleic acids research - 1 Apr 2008

Houzet Laurent, Morichaud Zakia, Didierlaurent Ludovic, Muriaux Delphine, Darlix Jean-Luc, Mougel Marylène

Abstract excerpt

Retroviruses replicate by converting their positive sense genomic RNA into double-stranded DNA that is subsequently integrated into the host genome. This conversion is catalyzed by reverse transcriptase (RT) early after virus entry into the target cell and is chaperoned by the nucleocapsid protein (NC). In HIV-1, NC is composed of small basic domains flanking two highly conserved CCHC zinc fingers that...

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Share to DNA Viruses
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18296486
DOI: 10.1093/nar/gkn069
PMCID: PMC2367716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nucleocapsid mutations turn HIV-1 into a DNA-containing virus.PMID 18296486Read ↗

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