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Role of HIV-1 nucleocapsid protein in HIV-1 reverse transcription

1 Nov 2010

Abstract excerpt

The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic acid structures so that the most thermodynamically stable conformations are formed. This activity is essential for virus replication and has a critical role in mediating highly specific and efficient reverse transcription. NC's function in this process depends upon three properties: (1) ability to aggregate nucleic acids; (2)...

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PMID: 21160280
DOI: 10.4161/rna.7.6.14115

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