Article
Interactions between HIV-1 nucleocapsid protein and viral DNA may have important functions in the viral life cycle.
Nucleic acids research - 25 Feb 1993
Lapadat-Tapolsky M, De Rocquigny H, Van Gent D, Roques B, Plasterk R, Darlix J L
Abstract excerpt
In the virion core of retroviruses, the genomic RNA is tightly associated with nucleocapsid (NC) protein molecules, forming the nucleocapsid structure. NC protein, a highly basic protein with two zinc fingers, is indispensable for RNA dimerization, encapsidation and the initiation of reverse tran...
Topics
- Amino Acid Sequence
- Base Sequence
- Capsid Proteins
- DNA Nucleotidyltransferases
- DNA Restriction Enzymes
- DNA, Single-Stranded
- DNA, Viral
- DNA-Binding Proteins
- Gene Products, gag
- HIV-1
- Integrases
- Molecular Sequence Data
- Mutation
- Structure-Activity Relationship
- Transcription, Genetic
- Viral Proteins
- Virus Replication
- Zinc Fingers