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Article

Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2013

Navarro Silvia, Medina Pilar, Bonet Elena, Corral Javier, Martínez-Sales Vicenta, Martos Laura, Rivera Miguel, Roselló-Lletí Esther, Alberca Ignacio, Roldán Vanessa, Mira Yolanda, Ferrando Fernando, Estellés Amparo, Vicente Vicente, Bertina Rogier M, España Francisco

Abstract excerpt

OBJECTIVE: To investigate the association of the THBD c.1418C>T polymorphism, which encodes for the replacement of Ala455 by Val in thrombomodulin (TM), with venous thromboembolism (VTE), plasma soluble TM, and activated protein C levels. In addition, human umbilical vein endothelial cells (HUVEC) isolated from 100 umbilical cords were used to analyze the relation between this polymorphism and THBD mRNA and TM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23520161
DOI: 10.1161/ATVBAHA.113.301360

Genes

THBD

Variants

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