Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress.

Free radical biology & medicine - 15 Jun 2004

Van Remmen Holly, Qi Wenbo, Sabia Marian, Freeman Gregory, Estlack Larry, Yang Hong, Mao Guo Zhong, Huang Ting-Ting, Strong Randy, Lee Shuko, Epstein Charles J, Richardson Arlan

Abstract excerpt

To examine the effect of compound deficiencies in antioxidant defense, we have generated mice (Sod2(+/-)/Gpx1(-/-)) that are deficient in Mn superoxide dismutase (MnSOD) and glutathione peroxidase 1 (Gpx1) by breeding Sod2(+/-) and Gpx1(-/-) mice together. Although Sod2(+/-)/Gpx1(-/-) mice showed a 50% reduction in MnSOD and no detectable Gpx1 activity in either mitochondria or cytosol in all tissues, they were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antioxidants
Share to Cytosol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gamma Rays

Share to Glutathione Peroxidase

Share to Myocardial Ischemia

Share to Paraquat

Share to Reperfusion Injury

Share to Superoxide Dismutase

Source

Identifiers

PMID: 15182862
DOI: 10.1016/j.freeradbiomed.2004.03.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress.PMID 15182862Read ↗

Spontaneous hypomorphic mutations in antioxidant enzymes of mice.Semantic proximity Read ↗

Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice.Semantic proximity Read ↗

Pathological Relationship between Intracellular Superoxide Metabolism and p53 Signaling in Mice.Semantic proximity Read ↗

Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse ModelSemantic proximity Read ↗

Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment.Semantic proximity Read ↗

Different extent of cardiac malfunction and resistance to oxidative stress in heterozygous and homozygous manganese-dependent superoxide dismutase-mutant mice.Semantic proximity Read ↗

Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.Semantic proximity Read ↗

Sod1 loss induces intrinsic superoxide accumulation leading to p53-mediated growth arrest and apoptosis.Semantic proximity Read ↗

Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice.Semantic proximity Read ↗

Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress.Semantic proximity Read ↗

Genetic modifier of mitochondrial superoxide dismutase-deficient mice delays heart failure and prolongs survival.Semantic proximity Read ↗

Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.