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APOE Genotype and Alzheimer's Disease: The Influence of Lifestyle and Environmental Factors.

ACS chemical neuroscience - 4 Aug 2021

Angelopoulou Efthalia, Paudel Yam Nath, Papageorgiou Sokratis G, Piperi Christina

Abstract excerpt

Alzheimer's disease (AD) is the most common neurodegenerative disorder with obscure pathogenesis and no disease-modifying therapy to date. AD is multifactorial disease that develops from the complex interplay of genetic factors and environmental exposures. The E4 allele of the gene encoding apolipoprotein E (APOE) is the most common genetic risk factor for AD, whereas the E2 allele acts in a protective manner. A...

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Identifiers

PMID: 34275270
DOI: 10.1021/acschemneuro.1c00295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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