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Article

Influence of the interleukin-6 -174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Oct 2004

McKenzie Jennifer A, Weiss Edward P, Ghiu Ioana A, Kulaputana Onanong, Phares Dana A, Ferrell Robert E, Hagberg James M

Abstract excerpt

A polymorphism in the IL-6 gene, a G-to-C substitution 176 bp upstream of the ATG translation initiation site, has been associated with diabetes prevalence and insulin resistance. Interventions including exercise training are frequently used to modify cardiovascular disease risk factors. Consequently, this project examined associations between the IL-6 -174 genotype and oral glucose tolerance test outcomes in 50-...

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Source

Identifiers

PMID: 15180970
DOI: 10.1152/japplphysiol.00199.2004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of the interleukin-6 -174 G/C gene polymorphism on exercise training-induced changes in glucose tolerance indexes.PMID 15180970Read ↗

Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene.Semantic proximity Read ↗

Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index.Semantic proximity Read ↗

Meta-analysis: Interleukin 6 gene -174G/C polymorphism associated with type 2 diabetes mellitus and interleukin 6 changes.Semantic proximity Read ↗

Interleukin-6 genotype is associated with high-density lipoprotein cholesterol responses to exercise training.Semantic proximity Read ↗

The IL-6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention.Semantic proximity Read ↗

Effect of the interleukin-6 (-174) g/c promoter polymorphism on adiponectin and insulin sensitivity.Semantic proximity Read ↗

BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham Study.Semantic proximity Read ↗

An IL-6 promoter variant (-174 G/C) augments IL-6 production and alters skeletal muscle transcription in response to exercise in mice.Semantic proximity Read ↗

A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus.Semantic proximity Read ↗

C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance.Semantic proximity Read ↗

Impact of interleukin 6 -174G>C polymorphism on obesity-related metabolic disorders in people with excess in body weight.Semantic proximity Read ↗

Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients.Semantic proximity Read ↗

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