Article
BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham Study.
Obesity (Silver Spring, Md.) - 1 Aug 2006
Herbert Alan, Liu Chunyu, Karamohamed Samer, Liu Jun, Manning Alisa, Fox Caroline S, Meigs James B, Cupples L Adrienne
Abstract excerpt
OBJECTIVE: The -174 interleukin (IL)-6 gene polymorphism has been proposed as a risk factor for type 2 diabetes, but data are conflicting. Because white fat is a major source of IL-6 in resting individuals, we tested the hypothesis that BMI modifies the association among the IL-6 genotype, insuli...
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