An IL-6 promoter variant (-174 G/C) augments IL-6 production and alters skeletal muscle transcription in response to exercise in mice.

doi:10.1152/japplphysiol.00391.2024

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

An IL-6 promoter variant (-174 G/C) augments IL-6 production and alters skeletal muscle transcription in response to exercise in mice.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jan 2025

Watson L E, MacRae C L, Kallingappa P, Cao Y, Li X, Hedges C P, D'Souza R F, Fleming N, Mellor K M, Merry T L

Abstract excerpt

Interleukin-6 (IL-6) is produced and secreted by skeletal muscle cells during exercise and plays an important role in mediating metabolic responses to exercise. The promoter region of the IL-6 gene contains a common genetic variant (-174 G/C, rs1800795), which may alter responses to exercise training. To isolate the impact of this gene variant on exercise-induced IL-6 expression and skeletal muscle transcription...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interleukin-6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice

Share to Mice, Inbred C57BL

Share to Muscle, Skeletal

Share to Physical Conditioning, Animal

Share to Promoter Regions, Genetic

Share to RNA, Messenger

Share to Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 39665197
DOI: 10.1152/japplphysiol.00391.2024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An IL-6 promoter variant (-174 G/C) augments IL-6 production and alters skeletal muscle transcription in response to exercise in mice.PMID 39665197Read ↗

The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity.Semantic proximity Read ↗

Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects.Semantic proximity Read ↗

A common polymorphism in the interleukin-6 gene promoter is associated with overweight.Semantic proximity Read ↗

Interleukin-6 (IL6) genotype is associated with fat-free mass in men but not women.Semantic proximity Read ↗

The IL-6 Gene Promoter SNP and Plasma IL-6 in Response to Diet Intervention.Semantic proximity Read ↗

Effect of the interleukin-6 (-174) g/c promoter polymorphism on adiponectin and insulin sensitivity.Semantic proximity Read ↗

Effects of 174 G/C polymorphism in the promoter region of the interleukin-6 gene on plasma IL-6 levels and muscle strength in elderly women.Semantic proximity Read ↗

A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus.Semantic proximity Read ↗

Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene.Semantic proximity Read ↗

IL-6 polymorphisms: a useful genetic tool for inflammation research?Semantic proximity Read ↗

Interleukin-6 -174 G/C promoter gene polymorphism and polycystic ovary syndrome: A cross sectional investigation in adult womenSemantic proximity Read ↗

Body composition changes after laparoscopic adjustable gastric banding: what is the role of -174G>C interleukin-6 promoter gene polymorphism in the therapeutic strategy?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.