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Article

C-174G polymorphism in the promoter of the interleukin-6 gene is associated with insulin resistance.

Diabetes care - 1 Aug 2005

Cardellini Marina, Perego Lucia, D'Adamo Monica, Marini Maria Adelaide, Procopio Cristina, Hribal Marta Letizia, Andreozzi Francesco, Frontoni Simona, Giacomelli Maurizio, Paganelli Michele, Pontiroli Antonio E, Lauro Renato, Folli Franco, Sesti Giorgio

Abstract excerpt

OBJECTIVE: The C-174G promoter polymorphism of the interleukin (IL)-6 gene was found to influence transcriptional activity and plasma IL-6 levels in humans. We addressed the question of whether the C-174G IL-6 polymorphism contributes to variation of insulin sensitivity. RESEARCH DESIGN AND METHODS: Two cohorts of subjects were genotyped. Cohort 1 includes 275 nondiabetic subjects who underwent a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 16043746
DOI: 10.2337/diacare.28.8.2007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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