Article
Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients.
Diabetes research and clinical practice - 1 Mar 2006
Testa R, Olivieri F, Bonfigli A R, Sirolla C, Boemi M, Marchegiani F, Marra M, Cenerelli S, Antonicelli R, Dolci A, Paolisso G, Franceschi C
Abstract excerpt
Interleukin-6 (IL-6), a powerful inflammatory mediator, plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. Recently, the IL-6 promoter polymorphism, at position -174 (G > C), has been associated to insulin sensitivity although contrasting data have been reported. The aim of this study was to evaluate the effect of the IL-6-174 G > C polymorphism on insulin resistance. In 238 type...
Topics
- Aged
- Blood Glucose
- Body Mass Index
- Diabetes Mellitus, Type 2
- Fasting
- Female
- Genotype
- Homeostasis
- Humans
- Insulin
- Insulin Resistance
- Interleukin-6
- Male
- Middle Aged