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Article

Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2004

Darash-Yahana Merav, Pikarsky Eli, Abramovitch Rinat, Zeira Evelyne, Pal Boaz, Karplus Rebekah, Beider Katia, Avniel Shani, Kasem Shafika, Galun Eithan, Peled Amnon

Abstract excerpt

Hormone refractory metastatic prostate cancer remains an incurable disease. We found that high expression levels of the chemokine receptor CXCR4 correlated with the presence of metastatic disease in prostate cancer patients. Positive staining for CXCL12, the ligand for CXCR4, was mainly present in the tumor-associated blood vessels and basal cell hyperplasia. Subcutaneous xenografts of PC3 and 22Rv1 prostate...

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Share to Bone Neoplasms
Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokines, CXC

Share to Hyperplasia

Share to Mice, Inbred NOD

Share to Neovascularization, Pathologic

Share to Receptors, CXCR4

Share to Transplantation, Heterologous

Source

Identifiers

PMID: 15180966
DOI: 10.1096/fj.03-0935fje

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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