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Article

Prostate cancer-derived CCN3 induces M2 macrophage infiltration and contributes to angiogenesis in prostate cancer microenvironment.

Oncotarget - 30 Mar 2014

Chen Po-Chun, Cheng Hsu-Chen, Wang John, Wang Shin-Wei, Tai Huai-Ching, Lin Chiao-Wen, Tang Chih-Hsin

Abstract excerpt

Tumor-associated macrophages (TAMs) are M2-polarized macrophages that infiltrate the tumor microenvironment and promote tumorigenesis. However, the mechanisms by which TAMs modulate prostate cancer (PCa) growth are poorly understood. Here, we found that expression of Nephroblastoma Overexpressed (NOV/CCN3) is upregulated in PCa cells and correlated with M2 macrophage infiltration. RAW264.7 macrophage migration...

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Source

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Identifiers

PMID: 24721786
DOI: 10.18632/oncotarget.1570
PMCID: PMC4039234

Genes

CCN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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