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Article

CXCR4 in breast cancer: oncogenic role and therapeutic targeting

1 Aug 2015

Abstract excerpt

Chemokines are 8-12 kDa peptides that function as chemoattractant cytokines and are involved in cell activation, differentiation, and trafficking. Chemokines bind to specific G-protein-coupled seven-span transmembrane receptors. Chemokines play a fundamental role in the regulation of a variety of cellular, physiological, and developmental processes. Their aberrant expression can lead to a variety of human...

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PMID: 26356032
DOI: 10.2147/dddt.s84932

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