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Article

Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2.

The Journal of biological chemistry - 6 May 2016

Fernandez-Caggiano Mariana, Schröder Ewald, Cho Hyun-Ju, Burgoyne Joseph, Barallobre-Barreiro Javier, Mayr Manuel, Eaton Philip

Abstract excerpt

The role and responses of the dimeric DJ-1 protein to cardiac oxidative stress is incompletely understood. H2O2 induces a 50-kDa DJ-1 interprotein homodimer disulfide, known to form between Cys-53 on each subunit. A trimeric 75-kDa DJ-1 complex that mass spectrometry shows contained 2-Cys peroxiredoxin also formed and precedes the appearance of the disulfide dimer. These observations may represent peroxiredoxin...

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Identifiers

PMID: 26945066
DOI: 10.1074/jbc.M115.699850
PMCID: PMC4858985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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