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Article

Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols.

Journal of the American Chemical Society - 16 Nov 2005

Stoyanovsky Detcho A, Tyurina Yulia Y, Tyurin Vladimir A, Anand Deepthi, Mandavia Dhara N, Gius David, Ivanova Juliana, Pitt Bruce, Billiar Timothy R, Kagan Valerian E

Abstract excerpt

The nitrosation of cellular thiols has attracted much interest as a regulatory mechanism that mediates some of the pathophysiological effects of nitric oxide (NO). In cells, virtually all enzymes contain cysteine residues that can be subjected to S-nitrosation, whereby this process often acts as an activity switch. Nitrosation of biological thiols is believed to be mediated by N2O3, metal-nitrosyl complexes, and...

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PMID: 16277524
DOI: 10.1021/ja0529135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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