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Article

The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress.

The Journal of biological chemistry - 24 Jan 2003

Xia Ling, Nordman Tomas, Olsson Jerker M, Damdimopoulos Anastassios, Björkhem-Bergman Linda, Nalvarte Ivan, Eriksson Lennart C, Arnér Elias S J, Spyrou Giannis, Björnstedt Mikael

Abstract excerpt

The selenoprotein thioredoxin reductase (TrxR1) is an essential antioxidant enzyme known to reduce many compounds in addition to thioredoxin, its principle protein substrate. Here we found that TrxR1 reduced ubiquinone-10 and thereby regenerated the antioxidant ubiquinol-10 (Q10), which is important for protection against lipid and protein peroxidation. The reduction was time- and dose-dependent, with an apparent...

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PMID: 12435734
DOI: 10.1074/jbc.M210456200

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