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Article

Inactivation of human peroxiredoxin I during catalysis as the result of the oxidation of the catalytic site cysteine to cysteine-sulfinic acid.

The Journal of biological chemistry - 11 Oct 2002

Yang Kap-Seok, Kang Sang Won, Woo Hyun Ae, Hwang Sung Chul, Chae Ho Zoon, Kim Kanghwa, Rhee Sue Goo

Abstract excerpt

By following peroxiredoxin I (Prx I)-dependent NADPH oxidation spectrophotometrically, we observed that Prx I activity decreased gradually with time. The decay in activity was coincident with the conversion of Prx I to a more acidic species as assessed by two-dimensional gel electrophoresis. Mass spectral analysis and studies with Cys mutants determined that this shift in pI was due to selective oxidation of the...

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Identifiers

PMID: 12161445
DOI: 10.1074/jbc.M206626200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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