Article
Unifying concept of DNA repair: the polymerase scanning hypothesis.
Environmental and molecular mutagenesis - 1 Jan 2000
Heddle John A, Bielas Jason H
Abstract excerpt
According to a series of experiments on untransformed mouse embryonic fibroblasts, quiescent mouse cells lack global genomic repair (GGR) of premutagenic DNA damage. The gene used to assess mutation and premutagenic DNA damage was the lacI transgene incorporated permanently in the DNA in a lambda shuttle vector. The transgene lacks mammalian transcription signals and thus is unexpressed in the cells. Although the...
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