Genetic defects, ionic currents and electrocardiographic alterations.

Abstract excerpt

Most experimental data on the kinetic properties of cardiac ion channels and their modification by genetic defects have been obtained in expression systems (e.g., Xenopus oocyte), away from the cellular environment where these channels function to generate the cardiac action potential. In this article, we describe the use of computational biology (computer simulations) in integrating such information on single...

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