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Article

Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia.

Nature - 5 Aug 1999

Clancy C E, Rudy Y

Abstract excerpt

Advances in genetics and molecular biology have provided an extensive body of information on the structure and function of the elementary building blocks of living systems. Genetic defects in membrane ion channels can disrupt the delicate balance of dynamic interactions between the ion channels and the cellular environment, leading to altered cell function. As ion-channel defects are typically studied in isolated...

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Identifiers

PMID: 10448858
DOI: 10.1038/23034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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