Article
Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.
Circulation - 12 Mar 2002
Clancy Colleen E, Rudy Yoram
Abstract excerpt
BACKGROUND: Complex physiological interactions determine the functional consequences of gene abnormalities and make mechanistic interpretation of phenotypes extremely difficult. A recent example is a single mutation in the C terminus of the cardiac Na(+) channel, 1795insD. The mutation causes two...
Topics
- Action Potentials
- Arrhythmias, Cardiac
- Computer Simulation
- Electrocardiography
- Heart Ventricles
- Humans
- Internet
- Ion Channel Gating
- Long QT Syndrome
- Markov Chains
- Models, Cardiovascular
- Mutation
- Myocardium
- NAV1.5 Voltage-Gated Sodium Channel
- Phenotype
- Reproducibility of Results
- Sodium
- Sodium Channels