Article
Adherence of infected erythrocytes to venular endothelium selects for antigenic variants of Plasmodium falciparum
1 Sept 1992
Abstract excerpt
Erythrocytes (E) infected with asexual forms of malaria parasites exhibit surface antigenic variation. In Plasmodium falciparum infections, the variant Ag is the P. falciparum E membrane protein 1 (PfEMP1). This molecule may also mediate the adherence of infected E to host venular endothelium. We show here that parasite lines selected for increased adherence to endothelial cells have undergone antigenic...
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