Article
Overlapping antigenic repertoires of variant antigens expressed on the surface of erythrocytes infected by Plasmodium falciparum.
Parasitology - 1 Jul 1999
Giha H A, Staalsoe T, Dodoo D, Elhassan I M, Roper C, Satti G M, Arnot D E, Hviid L, Theander T G
Abstract excerpt
Antibodies against variable antigens expressed on the surface of Plasmodium falciparum-infected erythrocytes are believed to be important for protection against malaria. A target for these antibodies is the P. falciparum erythrocyte membrane protein 1, PfEMP1, which is encoded by around 50 var genes and undergoes clonal variation. Using agglutination and mixed agglutination tests and flow cytometry to analyse the...
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