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Article

Allelic diversity of the Plasmodium falciparum erythrocyte membrane protein 1 entails variant-specific red cell surface epitopes.

PloS one - 27 Jan 2011

Vigan-Womas Inès, Guillotte Micheline, Juillerat Alexandre, Vallieres Cindy, Lewit-Bentley Anita, Tall Adama, Baril Laurence, Bentley Graham A, Mercereau-Puijalon Odile

Abstract excerpt

The clonally variant Plasmodium falciparum PfEMP1 adhesin is a virulence factor and a prime target of humoral immunity. It is encoded by a repertoire of functionally differentiated var genes, which display architectural diversity and allelic polymorphism. Their serological relationship is key to understanding the evolutionary constraints on this gene family and rational vaccine design. Here, we investigated the...

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PMID: 21298021
DOI: 10.1371/journal.pone.0016544
PMCID: PMC3029348

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Source receipt: pubmed, retrieved 7 Sept 2026.

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