Article
Rapid switching to multiple antigenic and adhesive phenotypes in malaria.
Nature - 25 Jun 1992
Roberts D J, Craig A G, Berendt A R, Pinches R, Nash G, Marsh K, Newbold C I
Abstract excerpt
Adhesion of parasitized erythrocytes to post-capillary venular endothelium or uninfected red cells is strongly implicated in the pathogenesis of severe Plasmodium falciparum malaria. Neoantigens at the infected red-cell surface adhere to a variety of host receptors, demonstrate serological diversity in field isolates and may also be a target of the host-protective immune response. Here we use sequential cloning...
Topics
- Animals
- Antigenic Variation
- Antigens, Protozoan
- Cell Adhesion
- Endothelium, Vascular
- Erythrocytes
- Humans
- Malaria, Falciparum
- Melanoma
- Phenotype
- Plasmodium falciparum