A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion.

doi:10.1038/sj.gene.6363919

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Article

A TaqI polymorphism in the 3'UTR of the IL-12 p40 gene correlates with increased IL-12 secretion.

Genes and immunity - 1 Nov 2002

Seegers D, Zwiers A, Strober W, Peña A S, Bouma G

Abstract excerpt

Interleukin-12 (IL-12) is a key cytokine for the induction of Th1 immune responses. We evaluated whether a TaqI polymorphism in the 3'UTR of the IL-12 p40 gene affects secretion of IL-12 in vitro, and whether this polymorphism is associated with susceptibility to Crohn's disease (CD). IL-12 p40 and p70 secretion by monocytes in relation to genotype was determined in 63 healthy donors. Genotype and allele...

Topics

3' Untranslated Regions
Adult
Aged
Crohn Disease
DNA
Deoxyribonucleases, Type II Site-Specific
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interleukin-12
Interleukin-12 Subunit p40
Male
Middle Aged
Monocytes
Polymorphism, Genetic
Protein Subunits

Source

Open in PubMed

Identifiers

PMID: 12424624
DOI: 10.1038/sj.gene.6363919

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