Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential gene expression in human brain pericytes induced by amyloid‐β protein

6 Feb 2004

Abstract excerpt

Cerebral amyloid angiopathy is one of the characteristics of Alzheimer's disease (AD) and this accumulation of fibrillar amyloid-beta (Alphabeta) in the vascular wall is accompanied by marked vascular damage. In vitro, Abeta1-40 carrying the 'Dutch' mutation (DAbeta1-40) induces degeneration of cultured human brain pericytes (HBP). To identify possible intracellular mediators of Abeta-induced cell death, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cancer-related Molecular Pathways
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15175081
DOI: 10.1111/j.1365-2990.2004.00536.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential gene expression in human brain pericytes induced by amyloid‐β proteinPMID 15175081Read ↗

Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease.Semantic proximity Read ↗

Amyloid-β protein precursor gene expression in alzheimer's disease and other conditions.Semantic proximity Read ↗

Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β ProteinSemantic proximity Read ↗

Cell cycle-related protein expression in vascular dementia and Alzheimer's diseaseSemantic proximity Read ↗

Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells.Semantic proximity Read ↗

Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein.Semantic proximity Read ↗

Insights into caspase-mediated apoptotic pathways induced by amyloid-β in cerebral microvascular endothelial cells.Semantic proximity Read ↗

Amyloid-beta-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype.Semantic proximity Read ↗

Altered cell cycle‐related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer’s disease [amyloid precursor protein/presenilin 1 (PS1)]Semantic proximity Read ↗

Swedish amyloid precursor protein mutation increases cell cycle-related proteins in vitro and in vivo.Semantic proximity Read ↗

Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls.Semantic proximity Read ↗

Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.