Article
Differential activation of mitochondrial apoptotic pathways by vasculotropic amyloid-beta variants in cells composing the cerebral vessel walls.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2010
Fossati S, Cam J, Meyerson J, Mezhericher E, Romero I A, Couraud P O, Weksler B B, Ghiso J, Rostagno A
Abstract excerpt
Cerebral amyloid angiopathy (CAA) is an age-associated condition and a common finding in Alzheimer's disease in which amyloid-beta (Abeta) vascular deposits are featured in >80% of the cases. Familial Abeta variants bearing substitutions at positions 21-23 are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The recently reported...
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