Article
Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease.
Acta neuropathologica - 1 Nov 2002
Rensink Annemieke A M, Gellekink Henkjan, Otte-Höller Irene, ten Donkelaar Hans J, de Waal Robert M W, Verbeek Marcel M, Kremer Berry
Abstract excerpt
Amyloid-beta (Abeta) deposition in cerebral blood vessel walls is one of the key features of Alzheimer's disease (AD). Abeta(1-40) carrying the "Dutch" mutation (DAbeta(1-40)) induces rapid degeneration of cultured human brain pericytes (HBP). To study the mechanisms of this Abeta-induced toxicity, a comparative cDNA expression array was performed to detect differential gene expression of Abeta-treated versus...
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