Article
Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease.
Acta neuropathologica - 1 Nov 2002
Rensink Annemieke A M, Gellekink Henkjan, Otte-Höller Irene, ten Donkelaar Hans J, de Waal Robert M W, Verbeek Marcel M, Kremer Berry
Abstract excerpt
Amyloid-beta (Abeta) deposition in cerebral blood vessel walls is one of the key features of Alzheimer's disease (AD). Abeta(1-40) carrying the "Dutch" mutation (DAbeta(1-40)) induces rapid degeneration of cultured human brain pericytes (HBP). To study the mechanisms of this Abeta-induced toxicit...
Topics
- Aged
- Alzheimer Disease
- Amyloid beta-Peptides
- Astrocytes
- Brain
- Cells, Cultured
- Cerebral Amyloid Angiopathy, Familial
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Female
- Gene Expression Profiling
- Growth Inhibitors
- Humans
- Immediate-Early Proteins