Insights into caspase-mediated apoptotic pathways induced by amyloid-β in cerebral microvascular endothelial cells.

Abstract excerpt

BACKGROUND: The vascular deposition of amyloid known as cerebral amyloid angiopathy (CAA)--an age-associated condition and a common finding in Alzheimer's disease--compromises cerebral blood flow, causing macro/microhemorrhages and/or cognitive impairment. Very little is known about the mechanisms causing CAA-related degeneration of cerebral vascular cells. The Dutch E22Q familial amyloid-β (Aβ) variant is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Caspases
• Share to Cell Line, Transformed
• Share to Cerebral Cortex