Article
Amyloid-β protein precursor gene expression in alzheimer's disease and other conditions.
Journal of Alzheimer's disease : JAD - 1 Jan 2012
Pottier Cyril, Wallon David, Lecrux Anne Rovelet, Maltete David, Bombois Stephanie, Jurici Snejana, Frebourg Thierry, Hannequin Didier, Campion Dominique
Abstract excerpt
Several lines of evidence suggest that AβPP gene expression could influence risk for Alzheimer's disease (AD). Using a highly sensitive multiplex fluorescent RT-PCR assay, we compared peripheral blood cells expression of AβPP mRNA among sporadic AD patients (n = 133), autosomal dominant early-onset AD cases (ADEOAD, n = 21), Down syndrome patients (n = 21), AD patients with AβPP duplication (n = 9), patients with...
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