Article
The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit.
Nucleic acids research - 1 Jan 2004
Sanchez Garcia Javier, Ciufo Leonora F, Yang Xiaowen, Kearsey Stephen E, MacNeill Stuart A
Abstract excerpt
DNA polymerase delta (Pol delta) plays a central role in eukaryotic chromosomal DNA replication, repair and recombination. In fission yeast, Pol delta is a tetrameric enzyme, comprising the catalytic subunit Pol3 and three smaller subunits, Cdc1, Cdc27 and Cdm1. Previous studies have demonstrated a direct interaction between Pol3 and Cdc1, the B-subunit of the complex. Here it is shown that removal of the tandem...
Topics
- Amino Acid Sequence
- Catalytic Domain
- Cell Cycle Proteins
- DNA Polymerase III
- Fungal Proteins
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Subunits
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Two-Hybrid System Techniques
- Zinc Fingers