Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair.

DNA repair - 5 Oct 2010

Brocas Clémentine, Charbonnier Jean-Baptiste, Dhérin Claudine, Gangloff Serge, Maloisel Laurent

Abstract excerpt

Eukaryotic DNA polymerase δ (Pol δ) activity is crucial for chromosome replication and DNA repair and thus, plays an essential role in genome stability. In Saccharomyces cerevisiae, Pol δ is a heterotrimeric complex composed of the catalytic subunit Pol3, the structural B subunit Pol31, and Pol32, an additional auxiliary subunit. Pol3 interacts with Pol31 thanks to its C-terminal domain (CTD) and this interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to DNA-Directed DNA Polymerase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Polymerase III

Share to DNA Replication

Share to Genes, Lethal

Share to Molecular Structure

Share to Proliferating Cell Nuclear Antigen

Share to Protein Structure, Secondary

Source

Identifiers

PMID: 20813592
DOI: 10.1016/j.dnarep.2010.07.013

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair.PMID 20813592Read ↗

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.Semantic proximity Read ↗

A novel variant of DNA polymerase ζ, Rev3ΔC, highlights differential regulation of Pol32 as a subunit of polymerase δ versus ζ in Saccharomyces cerevisiae.Semantic proximity Read ↗

Involvement of the yeast DNA polymerase delta in DNA repair in vivo.Semantic proximity Read ↗

Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae.Semantic proximity Read ↗

PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication.Semantic proximity Read ↗

Defect of Fe-S cluster binding by DNA polymerase δ in yeast suppresses UV-induced mutagenesis, but enhances DNA polymerase ζ - dependent spontaneous mutagenesis.Semantic proximity Read ↗

A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis.Semantic proximity Read ↗

Mgs1 and Rad18/Rad5/Mms2 are required for survival of Saccharomyces cerevisiae mutants with novel temperature/cold sensitive alleles of the DNA polymerase delta subunit, Pol31.Semantic proximity Read ↗

Structure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNA.Semantic proximity Read ↗

A role for DNA polymerase delta in gene conversion and crossing over during meiosis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Proficient Replication of the Yeast Genome by a Viral DNA Polymerase.Semantic proximity Read ↗

Regulation of human DNA polymerase delta in the cellular responses to DNA damageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.