Article
The influence of the Cdc27 subunit on the properties of the Schizosaccharomyces pombe DNA polymerase delta.
The Journal of biological chemistry - 27 Sept 2002
Bermudez Vladimir P, MacNeill Stuart A, Tappin Inger, Hurwitz Jerard
Abstract excerpt
Schizosaccharomyces pombe DNA polymerase (pol) delta contains four subunits, pol 3, Cdc1, Cdc27, and Cdm1. In this report, we examined the role of Cdc27 on the structure and activity of pol delta. We show that the four-subunit complex is monomeric in structure, in contrast to the previous report that it was a dimer (Zuo, S., Bermudez, V., Zhang, G., Kelman, Z., and Hurwitz, J. (2000) J. Biol. Chem. 275,...
Topics
- Amino Acid Motifs
- Cell Cycle Proteins
- Chromatography, Gel
- DNA
- DNA Polymerase III
- Electrophoresis, Polyacrylamide Gel
- Genetic Complementation Test
- Models, Chemical
- Mutation
- Proliferating Cell Nuclear Antigen