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Article

Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1.

The Journal of biological chemistry - 30 Jul 2004

Tanaka Katsunori, Russell Paul

Abstract excerpt

The protein kinase Cds1 is an effector of the replication checkpoint in the fission yeast Schizosaccharomyces pombe. Cds1 is required to stabilize stalled replication forks, and it helps to prevent the onset of mitosis until the genome is fully replicated. Mrc1 (mediator of the replication checkpoint-1) and Rad3-Rad26 kinase are required for Cds1 activation, but exactly how Mrc1 mediates Cds1 activation is...

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Identifiers

PMID: 15173168
DOI: 10.1074/jbc.M404834200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cds1 phosphorylation by Rad3-Rad26 kinase is mediated by forkhead-associated domain interaction with Mrc1.PMID 15173168Read ↗

Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast.Semantic proximity Read ↗

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Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60.Semantic proximity Read ↗

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe.Semantic proximity Read ↗

Activation of the DNA damage checkpoint in mutants defective in DNA replication initiation.Semantic proximity Read ↗

Cds1 controls the release of Cdc14-like phosphatase Flp1 from the nucleolus to drive full activation of the checkpoint response to replication stress in fission yeast.Semantic proximity Read ↗

DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe.Semantic proximity Read ↗

Schizosaccharomyces pombe Hsk1p is a potential cds1p target required for genome integrity.Semantic proximity Read ↗

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.Semantic proximity Read ↗

Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase.Semantic proximity Read ↗

Schizosaccharomyces pombe Cds1Chk2 regulates homologous recombination at stalled replication forks through the phosphorylation of recombination protein Rad60.Semantic proximity Read ↗

The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.Semantic proximity Read ↗

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