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Article

Genetically altered fields as origin of locally recurrent head and neck cancer: a retrospective study.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2004

Tabor Maarten P, Brakenhoff Ruud H, Ruijter-Schippers Henrique J, Kummer J Alain, Leemans C René, Braakhuis Boudewijn J M

Abstract excerpt

PURPOSE: Surgeons treating patients with head and neck squamous cell carcinoma (HNSCC) rely heavily on histology to decide whether the resection margins are tumor free and subsequent adjuvant treatments can be omitted. However, despite the presence of tumor-free margins, 10-30% of HNSCC patients still develop a locally recurrent tumor. Evidence is available that recurrent cancer develops from either (a)....

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Loss of Heterozygosity

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Share to Neoplasm, Residual

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Source

Identifiers

PMID: 15173066
DOI: 10.1158/1078-0432.CCR-03-0632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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